Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985075 | 0.98 | CHRM1 (0.41) | CHRM1SLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL497969 | 0.78 | IDO1 (0.50) | — | |
| SCHEMBL57120 | 0.77 | IDO1 (0.53) | CHRM1EPHX1 | |
| SCHEMBL16269909 | 0.75 | SLC6A2 (0.41) | CHRM1SLC6A2SLC6A4 | |
| SCHEMBL12052190 | 0.75 | RPS6KB1 (0.46) | CHRM1SLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL8249942 | 0.75 | RPS6KB1 (0.46) | CHRM1SLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL31489727 | 0.75 | HTR2A (0.55) | NPC1RAB9A | |
| SCHEMBL1396044 | 0.75 | RPS6KB1 (0.46) | CHRM1SLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL8941666 | 0.74 | IDO1 (0.46) | — | |
| SCHEMBL12052187 | 0.73 | RPS6KB1 (0.45) | CHRM1SLC6A2SLC6A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | claimed |
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |