Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315160 | 0.91 | EGFR (0.60) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8313473 | 0.90 | EGFR (0.59) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8318765 | 0.89 | EGFR (0.61) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8316697 | 0.89 | EGFR (0.58) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8313532 | 0.87 | EGFR (0.56) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8317113 | 0.86 | EGFR (0.59) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8317108 | 0.86 | EGFR (0.59) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315128 | 0.86 | EGFR (0.69) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8319428 | 0.85 | EGFR (0.73) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL7576084 | 0.85 | EGFR (0.55) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |