SCHEMBL6987757

SCHEMBL6987757

COC(=O)[C@H](CC1CC1)NC(=O)OCc1ccccn1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 0.51
HDAC1 Q13547 2/20 0.51
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
LMNA P02545 1/20 0.50
CNR2 P34972 2/20 0.44
MAPT P10636 1/20 0.44
NLRP3 Q96P20 1/20 0.44
KEAP1 Q14145 1/20 0.43
NFE2L2 Q16236 1/20 0.43
CTSL P07711 2/20 0.42
CTSB P07858 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
CTSS P25774 1/20 0.42
CTSK P43235 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6987816 0.89 NPC1 (0.54) HDAC6HDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL27492977 0.82 NPC1 (0.53) HDAC6HDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL7160572 0.82 NPC1 (0.53) HDAC6HDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL30764688 0.82 CTSK (0.59) SMN1; SMN2LMNAMAPTCTSLCTSB
SCHEMBL7469120 0.82 CTSK (0.59) SMN1; SMN2LMNAMAPTCTSLCTSB
SCHEMBL7086316 0.81 NPC1 (0.52) HDAC6HDAC1NPC1RAB9ASMN1; SMN2
SCHEMBL24021103 0.80 HDAC6 (0.53) HDAC6HDAC1NLRP3CTSSCTSK
SCHEMBL29063032 0.80 HDAC6 (0.53) HDAC6HDAC1NLRP3CTSSCTSK
SCHEMBL30008654 0.80 HDAC6 (0.53) HDAC6HDAC1NLRP3CTSSCTSK
SCHEMBL25762965 0.77 HDAC6 (0.57) HDAC6HDAC1SMN1; SMN2LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1093367-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2003-03-05 EP claimed
EP-1093367-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-04-25 EP claimed
WO-1999066925-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1999-12-29 WO claimed
EP-1093367-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2003-03-05 EP disclosed
EP-1093367-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-04-25 EP disclosed
WO-1999066925-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1999-12-29 WO disclosed