⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561465 | 0.65 | — | — | |
| SCHEMBL3835888 | 0.63 | HSP90AA1 (0.31) | — | |
| SCHEMBL8913616 | 0.63 | — | — | |
| SCHEMBL127479 | 0.58 | EGFR (0.50) | — | |
| SCHEMBL28003243 | 0.56 | EGFR (0.48) | — | |
| SCHEMBL15386176 | 0.55 | CDC25B (0.41) | — | |
| SCHEMBL30978396 | 0.55 | — | — | |
| SCHEMBL30481014 | 0.55 | — | — | |
| SCHEMBL1749731 | 0.55 | — | — | |
| SCHEMBL15326918 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056749-B1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2003-02-19 | — | — | EP | disclosed |
| EP-0840740-B1 | NEW INHIBITORS OF PLATELET AGGREGATION | ASTRAZENECA AB (SE) | 2002-05-02 | — | — | EP | disclosed |
| EP-0946561-B1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6297232-B1 | TREATMENT OF PLATELET AGGREGATION DISORDERS. | ASTRAZENECA AB (SE) | 2001-10-02 | — | — | US | disclosed |
| EP-0946561-A1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | Astra Pharmaceuticals Limited (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028300-A1 | TRIAZOLO[4,5-D]PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-07-02 | — | — | WO | disclosed |