Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.35 |
| ▸ | CCR8 | P51685 | 4/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.34 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778919 | 0.80 | GLO1 (0.37) | CCR1CCR8PDE4APDE4BPDE4C | |
| SCHEMBL662676 | 0.79 | KDM4E (0.47) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL1060220 | 0.76 | CCR1 (0.42) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL6986505 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4034477 | 0.75 | KDM4E (0.42) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7442849 | 0.74 | CCR1 (0.40) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL21438696 | 0.73 | KDM4E (0.41) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL6987990 | 0.73 | CCR1 (0.35) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7444371 | 0.73 | KDM4E (0.43) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL27513673 | 0.72 | KDM4E (0.39) | CCR1CCR8CCR5PSMD14COPS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363635-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | Merck & Co., Inc. (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1244628-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002069970-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK & CO., INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2001046151-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | disclosed |