SCHEMBL6988044

SCHEMBL6988044

Cc1ccc(C(=O)NO)c(Cl)n1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 4/20 0.58
HDAC1 Q13547 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
LMNA P02545 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
BRD4 O60885 1/20 0.39
SORT1 Q99523 2/20 0.38
ACLY P53396 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MMP3 P08254 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPK1 P28482 1/20 0.38
MAPT P10636 1/20 0.38
GRM5 P41594 1/20 0.38
KDM4E B2RXH2 1/20 0.37
MPO P05164 1/20 0.37
GAA P10253 1/20 0.37
HIF1A Q16665 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14469060 0.85 EGFR (0.57) EGFRLMNAL3MBTL1BRD4SORT1
SCHEMBL21256502 0.81 EGFR (0.54) EGFRLMNAL3MBTL1BRD4SORT1
SCHEMBL21676260 0.81 EGFR (0.54) EGFRALDH1A1MAPTGAA
SCHEMBL30027960 0.81 EGFR (0.54) EGFRLMNAL3MBTL1BRD4SMN1; SMN2
SCHEMBL921287 0.79 EGFR (0.54) EGFRLMNAL3MBTL1BRD4SORT1
SCHEMBL846877 0.79 EGFR (0.50) EGFRLMNAL3MBTL1SORT1ACLY
SCHEMBL400674 0.79 EGFR (0.54) EGFRLMNASORT1ACLYSMN1; SMN2
SCHEMBL7131171 0.78 EGFR (0.55) EGFRLMNAL3MBTL1SORT1GAA
SCHEMBL5438380 0.78 EGFR (0.51) EGFRSMN1; SMN2ALDH1A1
SCHEMBL2473897 0.78 EGFR (0.51) EGFRLMNABRD4SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779281-B1 ISOXAZOLES SANKYO CO (JP) 2003-10-29 EP disclosed
US-6096771-A ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 2000-08-01 US disclosed
US-5965591-A MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE SANKYO COMPANY, LIMITED (JP) 1999-10-12 US disclosed
EP-0779281-A1 ISOXAZOLES SANKYO COMPANY LIMITED (JP) 1997-06-18 EP disclosed