Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846877 | 0.83 | EGFR (0.50) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB | |
| SCHEMBL400674 | 0.83 | EGFR (0.54) | EGFRSMN1; SMN2ALDH1A1MAPK1ACLY | |
| Hydrochloric Acid SCHEMBL921288 | 0.82 | EGFR (0.53) | EGFRSMN1; SMN2ALDH1A1MAPK1ACLY | |
| SCHEMBL5190356 | 0.82 | POLB (0.52) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB | |
| SCHEMBL13952836 | 0.81 | GABRP (0.42) | EGFRSMN1; SMN2ALDH1A1ACLYPARP1 | |
| Hydrochloric Acid SCHEMBL5013614 | 0.80 | PARP1 (0.50) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB | |
| SCHEMBL14469060 | 0.79 | EGFR (0.57) | EGFRSMN1; SMN2ALDH1A1MAPK1ACLY | |
| SCHEMBL10001170 | 0.79 | EGFR (0.47) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB | |
| SCHEMBL10031554 | 0.79 | EGFR (0.47) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB | |
| SCHEMBL5425587 | 0.79 | EGFR (0.47) | EGFRSMN1; SMN2ALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100488962-C | Derivative of thiadiazoles containing cyclo oxdiazole, synthetic method, and biological activity | UNIV NANKAI (CN) | 2009-05-20 | — | — | CN | claimed |
| US-10626126-B2 | Compounds | PULMOCIDE LIMITED (GB) | 2020-04-21 | — | — | US | disclosed |
| US-20190256530-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, INC. | 2019-08-22 | — | — | US | disclosed |
| CN-109906224-A | TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF | 诺华股份有限公司 | 2019-06-18 | — | — | CN | disclosed |
| US-10301329-B2 | Boron-containing small molecules as antiprotozoal agents | ANACOR PHARMACEUTICALS, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20190092791-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2019-03-28 | — | — | US | disclosed |
| CN-108112251-A | NRF2 conditioning agents | 葛兰素史克知识产权发展有限公司 | 2018-06-01 | — | — | CN | disclosed |
| US-20170355718-A1 | Novel 5,6-Dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355718-A1 | Novel 5,6-Dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | PULMOCIDE LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| WO-2017175000-A1 | COMPOUNDS | PULMOCIDE LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |
| EP-1404668-A1 | VARIOLIN DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMA MAR, S.A. (ES) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003006457-A1 | VARIOLIN DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMA MAR, S.A. (ES) | 2003-01-23 | — | — | WO | disclosed |
| EP-0550900-A1 | Herbicidal and plant-nematocidal compositions based on mercaptonicotinic acid derivatives | BAYER AG (DE) | 1993-07-14 | — | — | EP | disclosed |
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| US-RE32975-E | FUNGICIDES, BACTERICIDES, FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-04 | — | — | US | disclosed |
| US-4808620-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETIC, ANTIALLERGENS, ANTIARTHRITIC, ANTIRHEUMATIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0254241-A1 | Pyrazolopyridine compounds, their preparation and use | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-01-27 | — | — | EP | disclosed |
| EP-0004279-B1 | PROCESS FOR THE PREPARATION OF 4-PYRIDONE-3-CARBOXYLIC ACIDS, 1-CYCLOPROPYL-4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES AND MEDICINES CONTAINING THEM | BAYER AG (DE) | 1982-12-29 | — | — | EP | disclosed |
| US-4284629-A | ANIMAL GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1981-08-18 | — | — | US | disclosed |
| EP-0004279-A1 | Process for the preparation of 4-pyridone-3-carboxylic acids, 1-cyclopropyl-4-pyridone-3-carboxylic acid derivatives and medicines containing them | BAYER AG (DE) | 1979-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626126-B2 | Compounds | QDPR, TXNRD2, TXNRD3 | EGFR 4499/4885SMN1; SMN2 239/4885ALDH1A1 932/4885 |
| US-20190092791-A1 | COMPOUNDS | QDPR, TXNRD2, TXNRD3 | EGFR 4499/4885SMN1; SMN2 239/4885ALDH1A1 932/4885 |
| US-10301329-B2 | Boron-containing small molecules as antiprotozoal agents | BTD, BAD, BRI3BP | EGFR 4823/4885SMN1; SMN2 3037/4885ALDH1A1 4684/4885 |
| US-20190256530-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | BTD, BAD, BRI3BP | EGFR 4823/4885SMN1; SMN2 3037/4885ALDH1A1 4684/4885 |
| US-20170355718-A1 | Novel 5,6-Dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives | DDX5, ZC3HAV1, MAVS | EGFR 3484/4885SMN1; SMN2 1075/4885ALDH1A1 2557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.