Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990991 | 0.88 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315389 | 0.86 | EGFR (0.52) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8316049 | 0.86 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8314431 | 0.86 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6994800 | 0.85 | EGFR (0.60) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6993701 | 0.85 | EGFR (0.64) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL4353386 | 0.83 | EGFR (0.58) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6994789 | 0.81 | EGFR (0.54) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315885 | 0.81 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6999525 | 0.81 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |