Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | METAP1 | P53582 | 3/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986009 | 0.99 | ADAM17 (0.40) | ADAM17TGFBR1METAP2METAP1CTSC | |
| SCHEMBL6982394 | 0.90 | ADAM17 (0.37) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6987093 | 0.88 | ADAM17 (0.44) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6987284 | 0.88 | ADAM17 (0.42) | ADAM17TGFBR1METAP2METAP1CTSC | |
| SCHEMBL6946853 | 0.87 | ADAM17 (0.50) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6984901 | 0.87 | ADAM17 (0.43) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6987120 | 0.87 | ADAM17 (0.43) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6988681 | 0.87 | ADAM17 (0.43) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6988787 | 0.87 | ADAM17 (0.47) | ADAM17TGFBR1CTSCP2RX3 | |
| SCHEMBL6986307 | 0.87 | ADAM17 (0.47) | ADAM17TGFBR1CTSCP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |