Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.50 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884828 | 0.93 | MAPT (0.62) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL28131280 | 0.86 | MAPT (0.67) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL1419188 | 0.84 | ALDH1A1 (1.00) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL29912570 | 0.83 | ALDH1A1 (0.97) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL1418324 | 0.83 | ALDH1A1 (0.97) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL3958592 | 0.82 | MAPT (0.73) | MAPTALDH1A1ALDH1A3LMNATDP1 | |
| SCHEMBL22278618 | 0.81 | MAPT (0.66) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL1418860 | 0.81 | MAPT (0.76) | MAPTALDH1A1ALDH1A3LMNATDP1 | |
| SCHEMBL3688210 | 0.81 | MAPT (0.76) | MAPTALDH1A1ALDH1A3MEN1KMT2A | |
| SCHEMBL30784403 | 0.81 | MAPT (0.70) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358169-A2 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057261-A2 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-25 | — | — | WO | disclosed |