Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421994 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL206164 | 0.84 | TSHR (0.58) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL30662861 | 0.84 | TSHR (0.58) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL13857741 | 0.83 | TSHR (0.53) | ALDH1A1MEN1KMT2APOLBHPGD | |
| SCHEMBL6551228 | 0.82 | TSHR (0.56) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL2521491 | 0.81 | HPGD (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL16957915 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL27746873 | 0.81 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL1032670 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL7369896 | 0.81 | TSHR (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |