Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900118 | 0.81 | BCHE (0.42) | NOTUMHSD11B1MAPTALDH1A1NPSR1 | |
| SCHEMBL5344492 | 0.72 | LMNA (0.46) | NOTUMKCNH2LMNAL3MBTL1HSD11B1 | |
| SCHEMBL17710261 | 0.72 | NOTUM (0.45) | NOTUMKCNH2LMNAL3MBTL1HSD11B1 | |
| SCHEMBL16201988 | 0.70 | MAPT (0.53) | NOTUMKCNH2LMNAL3MBTL1HSD11B1 | |
| SCHEMBL16201998 | 0.69 | KCNH2 (0.43) | NOTUMKCNH2LMNAL3MBTL1HSD11B1 | |
| SCHEMBL30725597 | 0.69 | KCNH2 (0.43) | NOTUMKCNH2LMNAL3MBTL1HSD11B1 | |
| SCHEMBL7227830 | 0.68 | NOTUM (0.44) | NOTUMKCNH2LMNAL3MBTL1TLR8 | |
| SCHEMBL2752537 | 0.68 | NOTUM (0.44) | NOTUMKCNH2LMNAL3MBTL1TLR8 | |
| SCHEMBL2752660 | 0.68 | NOTUM (0.44) | NOTUMKCNH2LMNAL3MBTL1TLR8 | |
| SCHEMBL30413222 | 0.68 | NOTUM (0.65) | NOTUMKCNH2L3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |