Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533665 | 1.00 | TSHR (0.67) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL13533666 | 1.00 | TSHR (0.67) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL10760741 | 0.87 | TSHR (0.63) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL10762307 | 0.81 | HPGD (0.69) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL13532862 | 0.81 | HPGD (0.69) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL2958047 | 0.81 | TSHR (0.69) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL11471890 | 0.81 | HPGD (0.73) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL11472575 | 0.81 | TSHR (0.69) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL16033027 | 0.80 | HPGD (1.00) | TSHRHPGDTP53CHRM2CHRM4 | |
| SCHEMBL10755797 | 0.79 | HPGD (0.65) | TSHRHPGDTP53CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061472-A | A pharmaceutical composition in the form of tablet and its preparation method | “瓦连塔印铁列克特”有限公司 | 2016-10-26 | — | — | CN | claimed |
| EP-1326829-A2 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE-II INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002026706-A2 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE-II INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2002-04-04 | — | — | WO | disclosed |