Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993767 | 0.90 | KCNH2 (0.51) | NAMPTKCNH2HRH2HRH1CD274 | |
| SCHEMBL7030896 | 0.87 | NAMPT (0.41) | NAMPTKCNH2HRH2HRH1CD274 | |
| SCHEMBL7030903 | 0.83 | NAMPT (0.40) | NAMPTKCNH2HRH2HRH1CD274 | |
| SCHEMBL6995821 | 0.79 | KCNH2 (0.53) | NAMPTKCNH2HRH2HRH1CD274 | |
| SCHEMBL7036069 | 0.78 | KCNH2 (0.52) | KCNH2HRH2HRH1CD274GLA | |
| SCHEMBL7028488 | 0.77 | CD274 (0.61) | NAMPTCD274DRD3EPHX2MKNK1 | |
| SCHEMBL6989327 | 0.75 | KCNH2 (0.49) | KCNH2CD274POLBHTT | |
| SCHEMBL7031260 | 0.72 | KCNH2 (0.58) | KCNH2GLAPOLBHTTSMN1; SMN2 | |
| SCHEMBL6997502 | 0.72 | KCNH2 (0.46) | KCNH2HRH2HRH1CD274POLB | |
| SCHEMBL6997557 | 0.71 | CCR3 (0.48) | NAMPTHRH2HRH1CD274DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |