Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031260 | 0.89 | KCNH2 (0.58) | KCNH2GRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL6322140 | 0.85 | GRIN1 (0.40) | KCNH2TRPV4GRIN1GRIN2BMEN1 | |
| SCHEMBL6743187 | 0.83 | GRIN1 (0.40) | KCNH2TRPV4HRH2HRH1HRH3 | |
| SCHEMBL6733487 | 0.82 | CHRNA7 (0.40) | KCNH2TRPV4HRH2HRH1HRH3 | |
| SCHEMBL7030295 | 0.81 | KCNH2 (0.39) | KCNH2TRPV4HRH2HRH1HRH3 | |
| SCHEMBL6995039 | 0.79 | GRIN1 (0.42) | KCNH2TRPV4HRH3GRIN1GRIN2B | |
| SCHEMBL6738018 | 0.79 | KCNH2 (0.39) | KCNH2TRPV4HRH2HRH1GRIN1 | |
| SCHEMBL1619314 | 0.78 | KCNH2 (0.72) | KCNH2MEN1KMT2APOLBKDM4E | |
| SCHEMBL3605800 | 0.78 | KCNH2 (0.72) | KCNH2MEN1KMT2APOLBKDM4E | |
| SCHEMBL6738989 | 0.78 | DPP4 (0.41) | KCNH2HRH3GRIN1GRIN2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |