Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988396 | 0.92 | HRH3 (0.47) | FABP4HRH3HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6994342 | 0.86 | FABP4 (0.50) | FABP4HRH3HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3700007 | 0.85 | HCRTR1 (0.56) | FABP4HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6988586 | 0.85 | FABP4 (0.52) | FABP4HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6987923 | 0.85 | FABP4 (0.58) | FABP4HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6989430 | 0.85 | HCRTR1 (0.50) | FABP4HRH3HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6990522 | 0.83 | NAMPT (0.47) | FABP4HRH3HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6989234 | 0.81 | HCRTR1 (0.58) | FABP4HRH3HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3699136 | 0.81 | FABP4 (0.56) | FABP4HCRTR1HCRTR2CYP3A4LMNA | |
| SCHEMBL3702050 | 0.81 | FABP4 (0.56) | FABP4HCRTR1HCRTR2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | FABP4, FABP1, FABP3 | FABP4 1/4885HRH3 4807/4885HCRTR1 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.