Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 6/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986603 | 0.85 | KMT2A (0.52) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL6988610 | 0.81 | KMT2A (0.51) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL7202062 | 0.79 | CYP2C9 (0.50) | KMT2AMEN1TSHRHTTALDH1A1 | |
| SCHEMBL4716454 | 0.75 | TSHR (0.43) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL7136407 | 0.75 | CYP2C9 (0.49) | KMT2AMEN1TSHRHTTALDH1A1 | |
| SCHEMBL4716453 | 0.74 | TSHR (0.42) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL4711947 | 0.73 | TSHR (0.41) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL5501969 | 0.73 | CA1 (0.54) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL5502622 | 0.69 | CA1 (0.52) | KMT2AMEN1TSHRHTTSMN1; SMN2 | |
| SCHEMBL6985272 | 0.68 | KMT2A (0.52) | KMT2AMEN1TSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |