SCHEMBL4716453

SCHEMBL4716453

[CH2]c1ccc(S(=O)(=O)NCC(CC)CCCC)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.42
HTT P42858 3/20 0.42
KMT2A Q03164 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 9/20 0.39
CYP3A4 P08684 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
GLA P06280 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LMNA P02545 3/20 0.37
KDM4E B2RXH2 1/20 0.36
HSD17B10 Q99714 1/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34
POLB P06746 1/20 0.33
MMP1 P03956 1/20 0.32
MMP2 P08253 1/20 0.32
MMP3 P08254 1/20 0.32
MMP9 P14780 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4716454 0.85 TSHR (0.43) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL4711947 0.83 TSHR (0.41) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL6986603 0.74 KMT2A (0.52) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL6989273 0.74 KMT2A (0.35) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL4713480 0.74 HTT (0.44) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL226294 0.73 ALDH1A1 (0.51) TSHRHTTKMT2ASMN1; SMN2ALDH1A1
SCHEMBL4025655 0.73 TSHR (0.40) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL3469704 0.72 GBA1 (0.55) TSHRKMT2AMEN1ALDH1A1CYP3A4
SCHEMBL4718006 0.72 KMT2A (0.39) TSHRHTTKMT2ASMN1; SMN2MEN1
SCHEMBL4711910 0.71 MAPT (0.40) LMNAMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1986637-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS Laboratoires Serono SA (CH) 2008-11-05 EP claimed
WO-2007093557-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS LABORATOIRES SERONO S.A. (CH) 2007-08-23 WO claimed
EP-1986637-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS Laboratoires Serono SA (CH) 2008-11-05 EP disclosed
WO-2007093557-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS LABORATOIRES SERONO S.A. (CH) 2007-08-23 WO disclosed