Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | DRD2 | P14416 | 8/20 | 0.65 |
| ▸ | DRD3 | P35462 | 8/20 | 0.65 |
| ▸ | HTR1A | P08908 | 6/20 | 0.65 |
| ▸ | HTR2A | P28223 | 5/20 | 0.65 |
| ▸ | HTR7 | P34969 | 5/20 | 0.65 |
| ▸ | DRD4 | P21917 | 3/20 | 0.65 |
| ▸ | DRD1 | P21728 | 4/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.61 |
| ▸ | DRD5 | P21918 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674703 | 0.95 | KCNH2 (0.72) | KCNH2POLBDRD2DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL3812906 | 0.94 | KCNH2 (0.70) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL1307947 | 0.90 | KCNH2 (0.64) | KCNH2POLBDRD2DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL2516709 | 0.89 | KCNH2 (0.62) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL4519313 | 0.89 | KCNH2 (0.85) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL26107525 | 0.89 | KCNH2 (0.85) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL26108725 | 0.89 | KCNH2 (0.85) | KCNH2POLBDRD2DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL26108256 | 0.87 | KCNH2 (0.83) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL13711971 | 0.87 | KCNH2 (0.71) | KCNH2POLBDRD2DRD3HTR1A | |
| SCHEMBL3683389 | 0.86 | KCNH2 (0.71) | KCNH2POLBDRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| CN-1332168-A | 3-substituted pyrido-[4',3':4,5] thieno-[2,3-d] pyrimidine derivatives, their prep. and use | BASF AG (DE) | 2002-01-23 | — | — | CN | disclosed |
| EP-1140096-A1 | UTILIZATION OF PYRIMIDINE DERIVATIVES FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | disclosed |
| US-6222034-B1 | AS SEROTININ RECEPTOR ANTAGONISTS; FOR THERAPY OF DEPRESSION, CENTRAL NERVOUS SYSTEM DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-24 | — | — | US | disclosed |
| WO-2000041695-A1 | UTILIZATION OF PYRIMIDINE DERIVATIVES FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |
| CN-1230962-A | 3-substituted pyrido [4',3':4,5] thieno [2, 3-d ] pyrimidine derivatives, their preparation and use | BASF AG (DE) | 1999-10-06 | — | — | CN | disclosed |
| EP-0927184-A1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998011110-A1 | 3-SUBSTITUTED PYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-19 | — | — | WO | disclosed |
| EP-0082402-B1 | SUCCINIMIDE DERIVATES AND PROCESS FOR PREPARATION THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-04-02 | — | — | EP | disclosed |
| US-4543355-A | Substituted succinimides, compositions and method of use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-09-24 | — | — | US | disclosed |
| US-4507303-A | Succinimide derivatives, compositions and method of use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-03-26 | — | — | US | disclosed |
| EP-0082402-A2 | Succinimide derivates and process for preparation thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-06-29 | — | — | EP | disclosed |