Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 6/20 | 0.67 |
| ▸ | HTR1A | P08908 | 6/20 | 0.67 |
| ▸ | DRD2 | P14416 | 6/20 | 0.67 |
| ▸ | HTR2A | P28223 | 6/20 | 0.67 |
| ▸ | HTR7 | P34969 | 6/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.67 |
| ▸ | DRD1 | P21728 | 4/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.64 |
| ▸ | DRD5 | P21918 | 3/20 | 0.64 |
| ▸ | HRH1 | P35367 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3812906 | 0.98 | KCNH2 (0.70) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL6989330 | 0.95 | KCNH2 (0.69) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL4519313 | 0.91 | KCNH2 (0.85) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL26108725 | 0.91 | KCNH2 (0.85) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL26107525 | 0.91 | KCNH2 (0.85) | KCNH2POLBDRD3HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL26108256 | 0.89 | KCNH2 (0.83) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL1307947 | 0.89 | KCNH2 (0.64) | KCNH2POLBDRD3HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL2516709 | 0.88 | KCNH2 (0.62) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL13711971 | 0.85 | KCNH2 (0.71) | KCNH2POLBDRD3HTR1ADRD2 | |
| SCHEMBL3683389 | 0.84 | KCNH2 (0.71) | KCNH2POLBDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | claimed |
| EP-2238125-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NeuroSearch A/S (DK) | 2010-10-13 | — | — | EP | claimed |
| WO-2009095438-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2009-08-06 | — | — | WO | claimed |
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | disclosed |
| EP-2238125-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NeuroSearch A/S (DK) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009095438-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2009-08-06 | — | — | WO | disclosed |
| US-7491727-B2 | Good selectivity, high affinity, metabolically stable 5-HT receptor modulators with good bioavailability, CNS penetration, and good pharmacokinetic; antiserotonine agents; central nervous system disorders; anxiolytic agents; attention deficit disorders; strokes; headaches | EPIX DELAWARE, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7491727-B2 | Good selectivity, high affinity, metabolically stable 5-HT receptor modulators with good bioavailability, CNS penetration, and good pharmacokinetic; antiserotonine agents; central nervous system disorders; anxiolytic agents; attention deficit disorders; strokes; headaches | EPIX DELAWARE, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7488731-B2 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488731-B2 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080027066-A1 | Arylpiperazinyl Compounds | EPIX DELAWARE, INC. | 2008-01-31 | — | — | US | disclosed |
| US-20080027066-A1 | Arylpiperazinyl Compounds | EPIX DELAWARE, INC. | 2008-01-31 | — | — | US | disclosed |
| US-20070004742-A1 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004742-A1 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. | 2007-01-04 | — | — | US | disclosed |
| EP-0290915-B1 | FLAVONE-3-CARBOXYLIC-ACID COMPOUNDS, AND PROCESS, INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Kali-Chemie Pharma GmbH (DE) | 1993-07-14 | — | — | EP | disclosed |
| US-5053508-A | Anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-10-01 | — | — | US | disclosed |
| US-5013852-A | Antiinflammatory | KALI-CHEMIE PHARMA GMBH (DE) | 1991-05-07 | — | — | US | disclosed |
| US-4886806-A | ANTIINFLAMMATORY AGENTS | KALI-CHEMIE PHARMA GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| EP-0290915-A2 | Flavone-3-carboxylic-acid compounds, and process, intermediates for their preparation and medicines containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1988-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027066-A1 | Arylpiperazinyl Compounds | HTR5A, HTR1A, HTR2A | KCNH2 1225/4885POLB 4265/4885DRD3 387/4885 |
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | HTR3A, HTR2A, HTR5A | KCNH2 828/4885POLB 4636/4885DRD3 14/4885 |
| US-20070004742-A1 | Arylpiperazinyl compounds | HTR5A, HTR1A, HTR2A | KCNH2 1225/4885POLB 4265/4885DRD3 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.