Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.67 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6702979 | 0.92 | DPP4 (0.67) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6993635 | 0.91 | DPP4 (0.66) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6703214 | 0.90 | DPP4 (0.69) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6990735 | 0.90 | DPP4 (0.64) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6700363 | 0.89 | DPP4 (0.68) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6697189 | 0.89 | DPP4 (0.64) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6702925 | 0.88 | DPP4 (0.63) | DPP4DPP7DPP8 | |
| Fumaric Acid SCHEMBL6703590 | 0.85 | DPP4 (0.73) | DPP4DPP7DPP8 | |
| SCHEMBL6702197 | 0.84 | DPP4 (0.70) | DPP4DPP7DPP8 | |
| SCHEMBL6989649 | 0.84 | DPP4 (0.70) | DPP4DPP7DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354882-A1 | DIPEPTIDYL PEPTIDASE IV INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-10-22 | — | — | EP | disclosed |