Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.49 |
| ▸ | FPR2 | P25090 | 6/20 | 0.43 |
| ▸ | FPR1 | P21462 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986574 | 0.98 | F10 (0.51) | F10FPR2FPR1LMNAKDM4E | |
| SCHEMBL6981553 | 0.83 | F10 (0.52) | F10FPR2FPR1MCHR1 | |
| SCHEMBL4680177 | 0.78 | F10 (0.80) | F10FPR2FPR1 | |
| SCHEMBL6981073 | 0.74 | F10 (0.56) | F10FPR2FPR1 | |
| SCHEMBL6984447 | 0.74 | F10 (0.43) | F10FPR2FPR1MCHR1 | |
| SCHEMBL6983572 | 0.73 | F10 (0.48) | F10FPR2MCHR1 | |
| SCHEMBL6987862 | 0.73 | F10 (0.54) | F10FPR2FPR1 | |
| SCHEMBL7452492 | 0.72 | F10 (0.42) | F10FPR2FPR1 | |
| SCHEMBL7091175 | 0.71 | F10 (0.46) | F10FPR2FPR1MCHR1 | |
| SCHEMBL27613671 | 0.71 | FPR1 (0.39) | F10FPR2FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337251-A1 | MONOCYCLIC OR BICYCLIC CARBOCYCLES AND HETEROCYCLES AS FACTOR XA INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002102380-A1 | MONOCYCLIC OR BICYCLIC CARBOCYCLES AND HETEROCYCLES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |