Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.49 |
| ▸ | SRC | P12931 | 7/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999979 | 0.87 | EGFR (0.44) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6997455 | 0.87 | MAP2K1 (0.42) | EGFRERBB2SRCMAP2K1PRKCQ | |
| SCHEMBL4455183 | 0.84 | EGFR (0.69) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6381073 | 0.83 | EGFR (0.69) | EGFRERBB2SRCGAKMAP2K1 | |
| SCHEMBL6998602 | 0.81 | MAP2K1 (0.62) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6382800 | 0.80 | EGFR (0.56) | EGFRERBB2SRCGAKMAP2K1 | |
| SCHEMBL6379771 | 0.80 | SRC (0.61) | EGFRERBB2SRCGAKMAP2K1 | |
| SCHEMBL6385365 | 0.79 | EGFR (0.69) | EGFRERBB2SRCGAKMAP2K1 | |
| SCHEMBL6379913 | 0.79 | EGFR (0.65) | EGFRERBB2SRCGAKMAP2K1 | |
| SCHEMBL7003514 | 0.78 | PRKCQ (0.59) | EGFRERBB2SRCGAKMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |