Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 12/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.37 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.37 |
| ▸ | STK4 | Q13043 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989870 | 0.87 | EGFR (0.49) | MAP2K1SRCEGFRERBB2PRKCQ | |
| SCHEMBL4450574 | 0.85 | MAP2K1 (0.58) | MAP2K1SRCEGFRERBB2 | |
| SCHEMBL6999979 | 0.82 | EGFR (0.44) | MAP2K1SRCEGFRERBB2STK4 | |
| SCHEMBL4455183 | 0.74 | EGFR (0.69) | MAP2K1SRCEGFRERBB2 | |
| SCHEMBL7001584 | 0.73 | MAP2K1 (0.73) | MAP2K1EGFRERBB2 | |
| SCHEMBL6998602 | 0.71 | MAP2K1 (0.62) | MAP2K1SRCEGFRERBB2 | |
| SCHEMBL6381073 | 0.71 | EGFR (0.69) | MAP2K1SRCEGFRERBB2PRKCQ | |
| SCHEMBL4448819 | 0.71 | EGFR (0.62) | MAP2K1SRCEGFRERBB2STK4 | |
| SCHEMBL6997360 | 0.71 | MAP2K1 (0.64) | MAP2K1SRCEGFRERBB2 | |
| SCHEMBL7000865 | 0.70 | SRC (0.43) | SRCEGFRERBB2WEE2WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |