Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488201 | 0.73 | TRPA1 (0.31) | TRPA1 | |
| SCHEMBL6998787 | 0.72 | TRPA1 (0.37) | MAP3K12TRPA1DRD2DRD4CHRNB2 | |
| SCHEMBL28114732 | 0.71 | CHRNB4 (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6991588 | 0.70 | TRPA1 (0.34) | MAP3K12TRPA1DRD2DRD4SCN9A | |
| SCHEMBL6996755 | 0.70 | TRPA1 (0.33) | TRPA1DRD2DRD4 | |
| SCHEMBL7000585 | 0.70 | TRPA1 (0.36) | TRPA1OPRM1OPRL1DRD2DRD4 | |
| SCHEMBL6998802 | 0.69 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL7962920 | 0.69 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL7000266 | 0.69 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL16565846 | 0.69 | OPRL1 (0.35) | TRPA1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946553-B1 | 8-AZABICYCLO 3.2.1]OCTANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES | SYNGENTA LTD (GB) | 2003-01-29 | — | — | EP | disclosed |
| US-6174894-B1 | Bicyclic amine derivatives | ZENECA LIMITED (GB) | 2001-01-16 | — | — | US | disclosed |
| US-6093726-A | AN INSECTICIDES, ACARICIDES OR NEMATICIDES | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |