Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.57 |
| ▸ | AGER | Q15109 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82589 | 0.82 | MAPT (0.65) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL26413518 | 0.82 | MAPT (0.65) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL5880406 | 0.82 | MAPT (0.65) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL30082691 | 0.80 | AGER (0.59) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL11335795 | 0.80 | MAPT (0.57) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL24770891 | 0.80 | CA12 (0.62) | MAPTMCOLN3GAAC5AR1AGER | |
| Dichloramine-T SCHEMBL151251 | 0.80 | MAPT (0.57) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL30108928 | 0.80 | MAPT (0.57) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL29963641 | 0.80 | APOBEC3G (0.60) | MAPTMCOLN3GAAC5AR1AGER | |
| SCHEMBL9811625 | 0.80 | MAPT (0.57) | MAPTMCOLN3GAAC5AR1AGER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589966-B1 | A family of hexadentate Fe(II) chelators having marked antiproliferative activity against tumor cells is disclosed. The cytotoxic metal chelators and complexes of the present invention are represented by the general formula below: | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2003-07-08 | — | — | US | disclosed |
| EP-0730616-B1 | PROCESS FOR PREPARING POLYAZAMACROCYCLES | DOW GLOBAL TECHNOLOGIES INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-5587451-A | Process for preparing polyazamacrocycles | THE DOW CHEMICAL COMPANY (US) | 1996-12-24 | — | — | US | disclosed |
| WO-1995014726-A1 | PROCESS FOR PREPARING POLYAZAMACROCYCLES | THE DOW CHEMICAL COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |
| US-4983376-A | Metal complexes | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-01-08 | — | — | US | disclosed |
| US-4001212-A | EXTRACT METAL IONS FROM SOLUTION AND COMPLEX | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |