Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997920 | 0.88 | EGFR (0.56) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL6996950 | 0.85 | EGFR (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL6996923 | 0.85 | EGFR (0.45) | EGFRERBB2ERBB4 | |
| SCHEMBL7001208 | 0.83 | EGFR (0.55) | EGFRERBB2GRM4GAKERBB3 | |
| SCHEMBL6989835 | 0.81 | EGFR (0.57) | EGFRERBB2GRM4GAKERBB3 | |
| SCHEMBL6993198 | 0.81 | EGFR (0.54) | EGFRERBB2ERBB4 | |
| SCHEMBL6993108 | 0.80 | EGFR (0.56) | EGFRERBB2ERBB4 | |
| SCHEMBL6409884 | 0.80 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL6993044 | 0.78 | EGFR (0.54) | EGFR | |
| SCHEMBL6991965 | 0.77 | EGFR (0.48) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |