Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917305 | 0.89 | KCNH2 (0.41) | KCNH2MEN1KMT2AMAPTNR1I2 | |
| SCHEMBL368929 | 0.88 | KCNH2 (0.39) | KCNH2MEN1KMT2AMAPTNR1I2 | |
| SCHEMBL9589800 | 0.81 | IKBKB (0.39) | KCNH2MEN1KMT2AMAPTNR1I2 | |
| SCHEMBL1512779 | 0.77 | GABRP (0.41) | KCNH2MEN1KMT2AMAPTLMNA | |
| SCHEMBL13281601 | 0.75 | KCNH2 (0.46) | KCNH2MEN1KMT2AMAPTPPARA | |
| SCHEMBL9590930 | 0.73 | GABRP (0.43) | MEN1KMT2AMAPTLMNACYP3A4 | |
| SCHEMBL3614621 | 0.72 | KDM4E (0.41) | MEN1KMT2AMAPTNR1I2LMNA | |
| SCHEMBL3924183 | 0.72 | KDM4E (0.41) | MEN1KMT2AMAPTNR1I2LMNA | |
| SCHEMBL3860802 | 0.72 | GABRP (0.46) | MEN1KMT2AMAPTLMNACYP3A4 | |
| SCHEMBL28647312 | 0.72 | MAPT (0.43) | MEN1KMT2AMAPTNR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423215-A1 | PRODRUGS BASED ON GEMCITABINE STRUCTURE AS WELL AS SYNTHETIC METHOD AND APPLICATION THEREOF | Sanlugen Pharmatech Ltd. (CN) | 2012-02-29 | — | — | EP | disclosed |