Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.55 |
| ▸ | JAK3 | P52333 | 7/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | OPA1 | O60313 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699938 | 0.93 | JAK2 (0.47) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL700324 | 0.87 | JAK2 (0.60) | JAK2JAK3HDAC1HDAC6HDAC3 | |
| SCHEMBL3348703 | 0.83 | HDAC1 (0.43) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL699344 | 0.82 | CDK2 (0.48) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL700350 | 0.80 | HDAC1 (0.61) | JAK2HDAC1JAK1HDAC6HDAC3 | |
| SCHEMBL700725 | 0.79 | CAMK2D (0.56) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL3353710 | 0.77 | HDAC1 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL699645 | 0.77 | CDK2 (0.67) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL199233 | 0.77 | HDAC1 (0.39) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3352879 | 0.76 | HDAC1 (0.38) | HDAC1HDAC6HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | JAK2 745/4885JAK3 1359/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.