Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982335 | 0.82 | CNR1 (0.56) | EGFRLCKMMP13MEN1KMT2A | |
| SCHEMBL30023908 | 0.78 | KDM4E (0.50) | CYP1A2CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL1990776 | 0.78 | KDM4E (0.50) | CYP1A2CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL20606513 | 0.75 | EGFR (0.59) | EGFRLCKMMP13CYP1A2CYP2D6 | |
| SCHEMBL11640078 | 0.75 | TSHR (0.60) | EGFRMMP13NPC1CYP1A2CYP2C19 | |
| SCHEMBL21753196 | 0.75 | HPGD (0.79) | EGFRMMP13CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL12447827 | 0.73 | NPC1 (0.49) | NPC1MEN1KMT2APOLBRAB9A | |
| SCHEMBL3281702 | 0.73 | KDM4E (0.50) | LCKNPC1CYP1A2CYP2C19MEN1 | |
| SCHEMBL8975296 | 0.73 | BCHE (0.72) | MMP13NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL6491776 | 0.72 | MMP13 (0.61) | EGFRMMP13CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |