Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 4/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989051 | 0.87 | RXFP1 (0.46) | PDE9APDE1CCD38KMT2AGAA | |
| SCHEMBL4926760 | 0.72 | MAPT (0.47) | ABL1SRCCYP3A4CD38EIF2AK1 | |
| SCHEMBL6986759 | 0.71 | PDE9A (0.35) | PDE9APDE1CKMT2ANPC1RAB9A | |
| SCHEMBL11552943 | 0.70 | PDE9A (0.61) | PDE9APDE1CCYP3A4KMT2AGAA | |
| SCHEMBL6989632 | 0.66 | GAA (0.40) | PDE9APDE1CABL1SRCKMT2A | |
| SCHEMBL6987924 | 0.66 | PDE9A (0.37) | PDE9APDE1CABL1CYP3A4 | |
| SCHEMBL6988191 | 0.65 | MAPT (0.41) | ABL1SRCCYP3A4CD38EIF2AK1 | |
| SCHEMBL10061644 | 0.62 | P2RX7 (0.44) | CYP3A4CD38EIF2AK1KMT2AKDM4E | |
| SCHEMBL4943568 | 0.62 | MAPT (0.56) | KMT2ARAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL3680016 | 0.61 | AHR (0.55) | PDE9APDE1CSRCCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303508-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2003-04-23 | — | — | EP | claimed |
| WO-2002006273-A1 | SUBSTITUTED 1-(4-AMINOPHENYL)INDOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | claimed |