Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994772 | 0.99 | USP2 (0.53) | USP2SMN1; SMN2HTTKAT6ACCKBR | |
| SCHEMBL7078089 | 0.89 | USP2 (0.44) | USP2SMN1; SMN2HTTKAT6ACCKBR | |
| SCHEMBL7077236 | 0.88 | MMP1 (0.52) | USP2SMN1; SMN2HTTKAT6ACYP3A4 | |
| SCHEMBL7084134 | 0.88 | KAT6A (0.44) | USP2SMN1; SMN2HTTKAT6ACCKBR | |
| SCHEMBL27589461 | 0.86 | CYP3A4 (0.48) | USP2SMN1; SMN2KAT6ACCKBRCYP3A4 | |
| SCHEMBL5675304 | 0.81 | USP2 (0.60) | USP2SMN1; SMN2HTTCYP1A2PLG | |
| SCHEMBL14676227 | 0.79 | USP2 (0.58) | USP2SMN1; SMN2HTTCYP1A2PLG | |
| SCHEMBL7079042 | 0.79 | CYP2D6 (0.48) | USP2SMN1; SMN2CYP3A4CYP1A2HIF1A | |
| SCHEMBL7066513 | 0.78 | USP2 (0.58) | USP2SMN1; SMN2HTTKAT6APLG | |
| SCHEMBL7066464 | 0.77 | HTT (0.57) | USP2SMN1; SMN2HTTPLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1443160-A | N-substituted-1-amino-1,1-dialkyl carboxylic acid derivatives | MERCK PATENT GMBH (DE) | 2003-09-17 | — | — | CN | disclosed |
| US-20030162814-A1 | N-substituted 1-amino-1,1-dialkylcarboxylic acid derivatives | MERCK PATENT GMBH (DE) | 2003-08-28 | — | — | US | disclosed |
| EP-1303482-A2 | N-SUBSTITUTED-1-AMINO-1,1-DIALKYLCARBOXYLIC ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008177-A2 | N-SUBSTITUTED-1-AMINO-1,1-DIALKYLCARBOXYLIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162814-A1 | N-substituted 1-amino-1,1-dialkylcarboxylic acid derivatives | F5, CCNY, F2 | USP2 3490/4885SMN1; SMN2 3251/4885HTT 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.