Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 9/20 | 0.48 |
| ▸ | NOS3 | P29474 | 4/20 | 0.47 |
| ▸ | NOS1 | P29475 | 4/20 | 0.47 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6995071 | 0.99 | HTR2A (0.49) | HTR2AHTR2CHTR1DNOS3NOS1 | |
| SCHEMBL27400361 | 0.92 | HTR2A (0.59) | HTR2AHTR2CHTR1DNOS3NOS1 | |
| SCHEMBL6996636 | 0.86 | ALDH1A1 (0.47) | HTR2AHTR2CHTR1DNOS3NOS1 | |
| SCHEMBL8430655 | 0.84 | ALDH1A1 (0.46) | KDM4EALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL6993894 | 0.83 | ALDH1A1 (0.50) | HTR1DKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL6990162 | 0.82 | ALDH1A1 (0.51) | HTR2AHTR2CHTR1DKDM4EALDH1A1 | |
| SCHEMBL9994932 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL6995817 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL8255718 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL8430662 | 0.81 | ALDH1A1 (0.48) | HTR2AHTR2CKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023898-B1 | Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| US-6239129-B1 | CHARACTERISED BY AN INDOLE RING ON THE AROMATIC MOIETY BY A CYANO GROUP AND ON THE INDOLE NITROGEN BY AN AMINOALKYL CHAIN. GREAT AFFINITY FOR 5-HT2C RECEPTORS, USEFUL FOR DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, | ADIR ET COMPAGNIE (FR) | 2001-05-29 | — | — | US | disclosed |
| EP-1023898-A1 | Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands | ADIR ET COMPAGNIE (FR) | 2000-08-02 | — | — | EP | disclosed |