Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | PRCP | P42785 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986787 | 0.80 | GID4 (0.55) | GID4MAOAOPRM1HTR2CPRCP | |
| SCHEMBL28686857 | 0.77 | GID4 (0.49) | GID4MAOAOPRM1HTR2CPRCP | |
| SCHEMBL3065108 | 0.76 | GID4 (1.00) | GID4MAOAOPRM1OPRK1PRCP | |
| SCHEMBL22728762 | 0.76 | GID4 (1.00) | GID4MAOAOPRM1OPRK1PRCP | |
| SCHEMBL29498352 | 0.76 | GID4 (1.00) | GID4MAOAOPRM1OPRK1PRCP | |
| SCHEMBL2792861 | 0.76 | GID4 (0.63) | GID4MAOAOPRM1HTR2CPRCP | |
| SCHEMBL2796297 | 0.76 | GID4 (0.63) | GID4MAOAOPRM1HTR2CPRCP | |
| SCHEMBL22728765 | 0.76 | GID4 (0.63) | GID4MAOAOPRM1HTR2CPRCP | |
| SCHEMBL28686856 | 0.75 | GID4 (0.52) | GID4OPRM1HTR2CPRCPDYRK1A | |
| SCHEMBL1704521 | 0.71 | ABL1 (0.62) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341765-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002046164-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-13 | — | — | WO | disclosed |