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Sugi Predict / Targets / GID4

GID4

Glucose-induced degradation protein 4 homolog · Q8IVV7 · GID4 on Sugi Atlas →

4,065 patent compounds predicted against GID4, 2,716 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2307452 SCHEMBL2307452 0.48 6/20
SCHEMBL2359018 SCHEMBL2359018 0.71 5/20
SCHEMBL4344078 SCHEMBL4344078 0.70 4/20
SCHEMBL4353119 SCHEMBL4353119 0.67 4/20
SCHEMBL5598091 SCHEMBL5598091 0.47 4/20
SCHEMBL4344185 SCHEMBL4344185 1.00 3/20
SCHEMBL325083 SCHEMBL325083 0.68 3/20
SCHEMBL327233 SCHEMBL327233 0.68 3/20
SCHEMBL1668148 SCHEMBL1668148 0.68 3/20
SCHEMBL1694744 SCHEMBL1694744 0.66 3/20
Potassium Potassium (SCHEMBL1694746) 0.66 3/20
SCHEMBL1694772 SCHEMBL1694772 0.66 3/20
SCHEMBL1694774 SCHEMBL1694774 0.66 3/20
SCHEMBL1694776 SCHEMBL1694776 0.66 3/20
SCHEMBL1694844 SCHEMBL1694844 0.66 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1735508) 0.66 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1735509) 0.66 3/20
SCHEMBL458574 SCHEMBL458574 0.62 3/20
SCHEMBL3140178 SCHEMBL3140178 0.60 3/20
SCHEMBL4344858 SCHEMBL4344858 0.60 3/20

Clinical trials — most relevant to GID4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients PHASE4UNKNOWN
Incretins in Impaired Fasting Glucose PHASE4COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes PHASE3COMPLETED
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA) PHASE3COMPLETED
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes PHASE2RECRUITING
Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction PHASE2RECRUITING
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
The Effects of Glucagon on Hepatic Metabolism PHASE1/PHASE2COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans PHASE1COMPLETED
Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PKs) of ZYDPLA1 Following Oral Administration in Healthy Volunteers PHASE1COMPLETED
The Role of TBC1D4 in Exercise- and Insulin-induced Glucose Metabolism in Human Skeletal Muscle nanCOMPLETED
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes nanRECRUITING
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People nanCOMPLETED
Influence of DPP-4 on Inflammatory Parameters in Diabetics: Gender Aspects nanUNKNOWN
VLCD & Adjuvant Exercise Effect in Overweight Diabetic Men nanCOMPLETED
Common Genetic Variation and Type 2 Diabetes nanCOMPLETED
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity nanCOMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging nanCOMPLETED
Exercise in Type 1 Diabetes Mellitus nanCOMPLETED
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism nanUNKNOWN
Effect of Dietary Glycemic Index on Beta-cell Function nanCOMPLETED
Effect of Liraglutide on Clock Genes nanUNKNOWN
Genetic Variation in CLTCL1 and Whole-body Glucose Control nanCOMPLETED
RESIST! Blood-flow Restriction Resistance Training for Improving Insulin Sensitivity in Type 2 Diabetes nanUNKNOWN
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GID4 binder may also engage these)

ProteinNameSimilarity
Q8C4U2 — 0.938 Q8C4U2 →
Q9Z1L3 — 0.933 Q9Z1L3 →
Q96MM7 — 0.932 Q96MM7 →
O09112 — 0.932 O09112 →
Q99NA9 — 0.932 Q99NA9 →
Q6A039 — 0.931 Q6A039 →
RASSF5 Ras association domain-containing protein 5 0.930 landscape →
O60347 — 0.930 O60347 →
APBA1 Amyloid-beta A4 precursor protein-binding fam 0.930 landscape →
Q9Z2K0 — 0.930 Q9Z2K0 →
Q9CXS4 — 0.930 Q9CXS4 →
Q5TGI4 — 0.929 Q5TGI4 →
Q80UW0 — 0.929 Q80UW0 →
Q5T6S3 — 0.929 Q5T6S3 →
Q7Z7K6 — 0.928 Q7Z7K6 →
Q5E9M5 — 0.928 Q5E9M5 →
Q61079 — 0.928 Q61079 →
O42224 — 0.927 O42224 →
O75446 — 0.927 O75446 →
M0R7T9 — 0.927 M0R7T9 →
Q6ZN54 — 0.927 Q6ZN54 →
Q01201 — 0.927 Q01201 →
O42148 — 0.927 O42148 →
O46606 — 0.927 O46606 →
B2RUJ5 — 0.927 B2RUJ5 →
Q04863 — 0.926 Q04863 →
Q5XI70 — 0.926 Q5XI70 →
Q8TBP0 — 0.926 Q8TBP0 →
Q09YL6 — 0.926 Q09YL6 →
Q14190 — 0.926 Q14190 →