Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.67 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.67 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.67 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.67 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.67 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.67 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.67 |
| ▸ | PIM1 | P11309 | 10/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699127 | 1.00 | FLT3 (0.67) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL700833 | 0.91 | FLT3 (0.75) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL700834 | 0.91 | FLT3 (0.75) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL10091756 | 0.91 | FLT3 (0.75) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL700203 | 0.87 | FLT3 (0.69) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL10091755 | 0.87 | FLT3 (0.69) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL700204 | 0.87 | FLT3 (0.69) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL10091635 | 0.80 | PIM1 (0.81) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL10091724 | 0.80 | PIM1 (0.55) | FLT3LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL701122 | 0.79 | PIM1 (0.57) | FLT3LRRK2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190669-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190669-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190669-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | US | disclosed |
| US-8124649-B2 | Oxindole compounds | CYLENE PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124649-B2 | Oxindole compounds | CYLENE PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124649-B2 | Oxindole compounds | CYLENE PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2307421-A1 | OXINDOLE COMPOUNDS | Cylene Pharmaceuticals, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20100041635-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
| US-20100041635-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
| US-20100041635-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
| WO-2010002933-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2010002933-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041635-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | FLT3 1/4885LRRK2 604/4885PSEN1 1780/4885 |
| US-20120190669-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | FLT3 1/4885LRRK2 604/4885PSEN1 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.