Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.69 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.69 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.69 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.69 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.69 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.69 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.69 |
| ▸ | PIM1 | P11309 | 6/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091755 | 1.00 | FLT3 (0.69) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL700204 | 1.00 | FLT3 (0.69) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL700833 | 0.96 | FLT3 (0.75) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10091756 | 0.96 | FLT3 (0.75) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL700834 | 0.96 | FLT3 (0.75) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL699126 | 0.87 | FLT3 (0.67) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL699127 | 0.87 | FLT3 (0.67) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10091724 | 0.82 | PIM1 (0.55) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL701122 | 0.82 | PIM1 (0.57) | FLT3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL701121 | 0.82 | PIM1 (0.57) | FLT3PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190669-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | US | disclosed |
| US-8124649-B2 | Oxindole compounds | CYLENE PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2307421-A1 | OXINDOLE COMPOUNDS | Cylene Pharmaceuticals, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20100041635-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
| WO-2010002933-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041635-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | FLT3 1/4885PSEN1 1780/4885PSEN2 1547/4885 |
| US-20120190669-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | FLT3 1/4885PSEN1 1780/4885PSEN2 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.