Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 12/20 | 0.74 |
| ▸ | AVPR1B | P47901 | 6/20 | 0.74 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.60 |
| ▸ | OXTR | P30559 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989046 | 0.85 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL7344881 | 0.85 | AVPR1A (0.72) | AVPR1AAVPR2OXTR | |
| SCHEMBL6987460 | 0.82 | AVPR1A (0.71) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989132 | 0.81 | AVPR1A (0.85) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6988098 | 0.81 | AVPR1A (0.74) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL8884989 | 0.78 | AVPR1A (0.65) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6987073 | 0.78 | AVPR1A (0.80) | AVPR1AAVPR1BAVPR2OXTRMAPT | |
| SCHEMBL6991954 | 0.78 | AVPR1A (0.65) | AVPR1AAVPR1BAVPR2MAPTTP53 | |
| SCHEMBL6990006 | 0.77 | AVPR1A (0.79) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6988528 | 0.77 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| US-5654297-A | CONGESTIVE HEART FAILURE, CARDIOVASCULAR DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996022294-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |