Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6995873 | 0.85 | KDM4E (0.56) | KDM4ECASP1ALDH1A1HPGDTDP1 | |
| SCHEMBL6992194 | 0.81 | KDM4E (0.52) | KDM4ECASP1ALDH1A1HPGDLMNA | |
| SCHEMBL12086851 | 0.76 | KDM4E (0.51) | KDM4EHTTALDH1A1HPGDTDP1 | |
| SCHEMBL15545075 | 0.75 | CGAS (0.53) | KDM4EHTTALDH1A1HPGDTDP1 | |
| SCHEMBL1614613 | 0.74 | KDM4E (0.72) | KDM4EHTTALDH1A1HPGDTDP1 | |
| SCHEMBL13788236 | 0.73 | KCNA3 (0.55) | KDM4EHTTCASP1ALDH1A1HPGD | |
| SCHEMBL6273762 | 0.73 | PLAU (0.59) | TDP1PLAUPLATLMNACYP3A4 | |
| SCHEMBL17154303 | 0.73 | CYP3A4 (0.44) | KDM4EALDH1A1HPGDGCGRLMNA | |
| SCHEMBL1536330 | 0.73 | PLAU (0.54) | KDM4EHTTALDH1A1HPGDTDP1 | |
| SCHEMBL9195201 | 0.71 | HTT (0.53) | KDM4EHTTCASP1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| CN-1275979-A | Isoquinoline compounds useful as urokinase inhibitors | PFIZER (US) | 2000-12-06 | — | — | CN | disclosed |