SCHEMBL6991605

SCHEMBL6991605

CC(CSCc1ccccc1)CC(=O)O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.51
ACE P12821 2/20 0.49
CASP3 P42574 4/20 0.44
CASP8 Q14790 4/20 0.44
CASP1 P29466 3/20 0.44
CASP7 P55210 3/20 0.44
CPA1 P15085 2/20 0.43
CPB1 P15086 1/20 0.43
CPA3 P15088 1/20 0.43
CPB2 Q96IY4 1/20 0.43
METAP2 P50579 1/20 0.43
PPARG P37231 1/20 0.43
PPARA Q07869 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20408407 0.83 ACE (0.46) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL25220488 0.83 ACE (0.54) CYP2C19ACEPPARGPPARA
SCHEMBL20395348 0.82 CYP2C19 (0.55) CYP2C19ACECPA1CPB1CPA3
SCHEMBL5179571 0.81 CYP2C19 (0.53) CYP2C19ACECASP3CASP8CASP1
SCHEMBL16181502 0.80 TRPA1 (0.46) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL1357871 0.79 ACE (0.58) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL10268771 0.79 ACE (0.58) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL1741031 0.79 ACE (0.58) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL9906423 0.78 ACE (0.43) CYP2C19ACEMETAP2PPARGPPARA
SCHEMBL20412172 0.78 CYP2C19 (0.50) CYP2C19ACECPA1CPB1CPA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1339692-A1 NOVEL COMPOUNDS FOR USE AS HIV PROTEASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2003-09-03 EP disclosed
WO-2002042277-A1 NOVEL COMPOUNDS FOR USE AS HIV PROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2002-05-30 WO disclosed