Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 9/20 | 0.67 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.67 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990757 | 0.86 | AVPR1A (0.64) | AVPR1AAVPR1BAVPR2GAAMAPT | |
| SCHEMBL6989132 | 0.80 | AVPR1A (0.85) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6989046 | 0.80 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL6988098 | 0.80 | AVPR1A (0.74) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7365160 | 0.80 | AVPR1A (0.68) | AVPR1AAVPR1BAVPR2MAPTMEN1 | |
| SCHEMBL8316362 | 0.79 | AVPR2 (0.48) | AVPR1AAVPR2 | |
| SCHEMBL8799494 | 0.79 | AVPR1A (0.65) | AVPR1AAVPR1BAVPR2MAPTMEN1 | |
| SCHEMBL6988520 | 0.78 | AVPR1A (0.66) | AVPR1AAVPR1BAVPR2MAPTMEN1 | |
| SCHEMBL6988528 | 0.78 | AVPR1A (1.00) | AVPR1AAVPR1BAVPR2OXTR | |
| SCHEMBL8796814 | 0.78 | AVPR1A (0.77) | AVPR1AAVPR1BAVPR2GAAOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-B1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0811008-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | disclosed |