Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.45 |
| ▸ | MERTK | Q12866 | 3/20 | 0.45 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991823 | 1.00 | BRAF (0.49) | BRAFCSNK2A1MAPK8MAPK9CDK1 | |
| SCHEMBL6994075 | 0.90 | EGFR (0.51) | BRAFMAPK8MAPK9EGFRERBB2 | |
| SCHEMBL6994082 | 0.90 | EGFR (0.51) | BRAFMAPK8MAPK9EGFRERBB2 | |
| SCHEMBL6994605 | 0.89 | BRAF (0.51) | BRAFCSNK2A1MAPK8MAPK9CDK1 | |
| SCHEMBL6994609 | 0.89 | BRAF (0.51) | BRAFCSNK2A1MAPK8MAPK9CDK1 | |
| SCHEMBL6993773 | 0.86 | BRAF (0.53) | BRAFMAPK8MAPK9CDK1EGFR | |
| SCHEMBL6993782 | 0.86 | BRAF (0.53) | BRAFMAPK8MAPK9CDK1EGFR | |
| SCHEMBL6998715 | 0.84 | BRAF (0.50) | BRAFCSNK2A1CDK1EGFRERBB2 | |
| SCHEMBL8317921 | 0.84 | BRAF (0.52) | BRAFCSNK2A1MAPK8MAPK9CDK1 | |
| SCHEMBL8317917 | 0.84 | BRAF (0.52) | BRAFCSNK2A1MAPK8MAPK9CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |