Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386083 | 0.86 | IGF1R (0.53) | IGF1REGFRERBB2SRCMAP2K1 | |
| SCHEMBL6997884 | 0.86 | MAP2K1 (0.63) | IGF1REGFRERBB2SRCMAP2K1 | |
| SCHEMBL4450579 | 0.85 | EGFR (0.70) | IGF1REGFRERBB2SRCMAP2K1 | |
| SCHEMBL6379771 | 0.84 | SRC (0.61) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL7000625 | 0.84 | MAP2K1 (0.53) | IGF1REGFRERBB2MAP2K1 | |
| SCHEMBL6384318 | 0.84 | EGFR (0.70) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6382227 | 0.83 | EGFR (0.70) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL7000398 | 0.83 | IGF1R (0.75) | IGF1REGFRERBB2MAP2K1 | |
| SCHEMBL6995272 | 0.82 | MAP2K1 (0.50) | IGF1REGFRERBB2MAP2K1 | |
| SCHEMBL6386079 | 0.81 | EGFR (0.67) | EGFRERBB2SRCMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |