Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.46 |
| ▸ | STK4 | Q13043 | 5/20 | 0.45 |
| ▸ | IGF1R | P08069 | 7/20 | 0.42 |
| ▸ | STK3 | Q13188 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000625 | 0.88 | MAP2K1 (0.53) | MAP2K1EGFRERBB2STK4IGF1R | |
| SCHEMBL2203293 | 0.87 | MAP2K1 (0.59) | MAP2K1EGFRERBB2STK4IGF1R | |
| SCHEMBL6992049 | 0.82 | IGF1R (0.51) | MAP2K1EGFRERBB2IGF1R | |
| SCHEMBL6999694 | 0.81 | MAP2K1 (0.52) | MAP2K1EGFRERBB2STK4IGF1R | |
| SCHEMBL2203540 | 0.81 | MAP2K1 (0.58) | MAP2K1EGFRERBB2STK4IGF1R | |
| SCHEMBL6998421 | 0.80 | EGFR (0.56) | MAP2K1EGFRERBB2STK4STK3 | |
| SCHEMBL2203726 | 0.80 | MAP2K1 (0.63) | MAP2K1EGFRERBB2STK4IGF1R | |
| SCHEMBL6998072 | 0.78 | MAP2K1 (0.57) | MAP2K1EGFRERBB2IGF1R | |
| SCHEMBL7001957 | 0.77 | IGF1R (0.71) | MAP2K1EGFRERBB2IGF1R | |
| SCHEMBL6996969 | 0.77 | EGFR (0.57) | MAP2K1EGFRERBB2STK4STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |