Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 19/20 | 0.59 |
| ▸ | HTR1B | P28222 | 19/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 19/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 19/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992474 | 0.94 | HTR1A (0.53) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6998104 | 0.88 | HTR1A (0.74) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7717801 | 0.83 | HTR1A (0.81) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6992475 | 0.83 | HTR1A (0.66) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7718492 | 0.83 | HTR1A (0.66) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7719545 | 0.82 | HTR1A (0.80) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6991375 | 0.80 | HTR1A (0.51) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6993889 | 0.80 | HTR1A (0.50) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7719473 | 0.80 | HTR1A (0.72) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6995966 | 0.80 | HTR1A (0.72) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |