Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998973 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TDP2DRD2DRD4DRD3 | |
| SCHEMBL6998254 | 0.70 | ELANE (0.40) | ALDH1A1DRD2DRD4DRD3KDM4E | |
| SCHEMBL4341946 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL9081301 | 0.67 | KDM4E (0.49) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1459965 | 0.66 | GRIA1 (0.53) | ALDH1A1TDP2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL18289479 | 0.66 | AHR (0.50) | DRD2DRD4DRD3KDM4ELMNA | |
| SCHEMBL16047379 | 0.66 | CYP1A2 (0.56) | TDP2AHRPDK2CHEK1AURKA | |
| SCHEMBL24477031 | 0.65 | KDM4E (0.44) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL29724159 | 0.65 | KDM4E (0.44) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL5843496 | 0.65 | JAK2 (0.51) | ALDH1A1DRD2DRD4DRD3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149106-B1 | 4,5-AZOLO-OXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | EP | claimed |
| EP-1149106-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| WO-2000035920-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149106-B1 | 4,5-AZOLO-OXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | EP | disclosed |
| EP-1149106-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6197804-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-06 | — | — | US | disclosed |
| US-6153634-A | FOR THERAPY AND PROPHYLAXIS OF CANCER TUMORS; INHIBITOR OFCYCLIN-DEPENDENT KINASES (CDKS) | HOFFMANN-LA ROCHE INC. (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000035920-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |