Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756770 | 0.82 | KDM4E (0.53) | KMT2AMEN1LMNACNR1KDM4E | |
| SCHEMBL5758311 | 0.78 | LMNA (0.47) | KMT2AMEN1LMNACNR1UBASH3B | |
| SCHEMBL17025452 | 0.77 | KDM4E (0.49) | KMT2AMEN1LMNACNR1KDM4E | |
| SCHEMBL5782115 | 0.75 | KMT2A (0.66) | KMT2AMEN1NPC1KDM4EALDH1A1 | |
| Water SCHEMBL5782423 | 0.74 | KMT2A (0.51) | KMT2AMEN1NPC1KDM4EALDH1A1 | |
| SCHEMBL1538310 | 0.71 | MEN1 (0.59) | KMT2AMEN1LMNAKDM4EUBASH3B | |
| SCHEMBL5780432 | 0.71 | RXFP1 (0.52) | KMT2AMEN1LMNACNR1L3MBTL1 | |
| SCHEMBL5756005 | 0.69 | MEN1 (0.44) | KMT2AMEN1LMNACNR1UBASH3B | |
| SCHEMBL5781874 | 0.69 | RHEB (0.48) | KMT2AMEN1LMNANPC1L3MBTL1 | |
| SCHEMBL5514658 | 0.68 | MAPT (0.53) | KMT2AMEN1NPC1CNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351954-A1 | FARNESYL TRANSFERASE INHIBITING 4-HETEROCYCLYL-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002051834-A1 | FARNESYL TRANSFERASE INHIBITING 4-HETEROCYCLYL-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-07-04 | — | — | WO | disclosed |