SCHEMBL6992809

SCHEMBL6992809

CC1Oc2ccc(C(N)C(=O)OC(C)(C)CCc3cccc(C(F)(F)F)c3)cc2NC1=O

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 4/20 0.40
DAO P14920 2/20 0.37
GRM2 Q14416 1/20 0.35
GRM3 Q14832 1/20 0.35
SMYD3 Q9H7B4 3/20 0.35
USP2 O75604 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
HSD17B10 Q99714 1/20 0.35
EPHX1 P07099 2/20 0.33
DHODH Q02127 1/20 0.33
MMP1 P03956 1/20 0.33
MMP12 P39900 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7000920 0.90 PARP1 (0.41) PARP1DAOSMYD3
SCHEMBL6994403 0.89 PARP1 (0.41) PARP1DAOGRM2GRM3SMYD3
SCHEMBL6998537 0.88 PARP1 (0.41) PARP1DAOGRM2GRM3SMYD3
SCHEMBL6996238 0.86 PARP1 (0.41) PARP1SMYD3USP2
SCHEMBL7000745 0.86 PARP1 (0.39) PARP1SMYD3MAPT
SCHEMBL7000925 0.85 PARP1 (0.42) PARP1SMYD3USP2
SCHEMBL7001012 0.84 PARP1 (0.40) PARP1SMYD3
SCHEMBL6999457 0.84 PARP1 (0.42) PARP1SMYD3HSD17B10
SCHEMBL6996225 0.84 PARP1 (0.39) PARP1SMYD3
SCHEMBL6995124 0.83 PARP1 (0.41) PARP1DAOSMYD3MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed