Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 15/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002714 | 0.90 | PTGS2 (0.39) | PTGS2 | |
| SCHEMBL6997158 | 0.89 | PTGS2 (0.40) | CYP3A4CYP2C9PTGS2JAK2JAK3 | |
| SCHEMBL7003059 | 0.85 | FLT3 (0.41) | PTGS2PTGS1MELK | |
| SCHEMBL7004874 | 0.82 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL6997713 | 0.82 | PTGS2 (0.40) | PTGS2PTGS1MELK | |
| SCHEMBL7001297 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL7000766 | 0.80 | PTGS2 (0.38) | PTGS2 | |
| SCHEMBL6999178 | 0.78 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL7002833 | 0.78 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL6994499 | 0.77 | PTGS2 (0.42) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |