Sugi Predict

Sugi Predict / Compounds / SCHEMBL69930

SCHEMBL69930

SCHEMBL69930

COc1ccccc1-c1cc(C(=O)NCC(=O)N2CCC(Nc3ccccc3Cl)CC2)n[nH]1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ SCD O00767 2/20 0.43
▸ P2RY12 Q9H244 5/20 0.42
▸ KMT2A Q03164 2/20 0.41
▸ RAB9A P51151 1/20 0.40
▸ KDM5A P29375 1/20 0.39
▸ EPHX2 P34913 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ IGF1R P08069 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29385122 1.00 SCD (0.43) SCDP2RY12KMT2ARAB9AKDM5A
SCHEMBL92228 0.90 P2RY12 (0.41) SCDP2RY12KMT2AKDM5AEPHX2
SCHEMBL68650 0.89 SCD (0.46) SCDKMT2AKDM5AMEN1
SCHEMBL70754 0.88 KMT2A (0.41) SCDKMT2ARAB9AKDM5AEPHX2
SCHEMBL29385518 0.88 KMT2A (0.41) SCDKMT2ARAB9AKDM5AEPHX2
SCHEMBL68350 0.88 KMT2A (0.41) SCDKMT2AKDM5AEPHX2SMN1; SMN2
SCHEMBL29385005 0.88 KMT2A (0.41) SCDKMT2AKDM5AEPHX2SMN1; SMN2
SCHEMBL70832 0.86 SCD (0.43) SCDP2RY12KMT2AKDM5AEPHX2
SCHEMBL29385641 0.85 SCD (0.46) SCDKMT2AEPHX2
SCHEMBL70596 0.85 SCD (0.46) SCDKMT2AEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268143-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE Forest Laboratories Holdings Limited (BM) 2011-01-05 — — EP claimed
US-8129376-B2 Piperidine derivatives as inhibitors of stearoyl-CoA desaturase AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-03-06 — — US disclosed
US-8129376-B2 Piperidine derivatives as inhibitors of stearoyl-CoA desaturase AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-03-06 — — US disclosed
EP-2268143-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE Forest Laboratories Holdings Limited (BM) 2011-01-05 — — EP disclosed
WO-2009117676-A2 NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — WO disclosed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — US disclosed
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE FOREST LABORATORIES HOLDINGS LIMITED (BM) 2009-09-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239810-A1 NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE SCD, SCD5, FADS2 SCD 1/4885P2RY12 3918/4885KMT2A 1352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.